-localization of drug effects at subcellular resolution-

We developed Molecular Tattoo, a novel tool in optopharmacology.

It enables localization of drug effects at subcellular resolution in live biological objects including whole animals. Molecular Tattoo combines photoaffinity-labeling with two-photon microscopy. Precise sequential laser irradiation is used to covalently enrich low concentration photoreactive drugs on their specific targets. This results in a strong and permanent drug effect that is restricted solely to the irradiated area.

Main features:

  • precise and permanent effect localization
  • no systemic and side effects outside the target area
  • scaling of the targeted area: from organs or cell groups down to subfemtoliter volumes
  • the usual in vitro and in vivo samples can be used without genetic modification.

For more information, please go to moleculartattoo.com


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